DEGRADATION OF A THIN POLYMER FILM STUDIED BY SIMULTANEOUS IN-SITU ATOMIC FORCE MICROSCOPY AND SURFACE-PLASMON RESONANCE ANALYSIS

被引:39
作者
CHEN, X [1 ]
SHAKESHEFF, KM [1 ]
DAVIES, MC [1 ]
HELLER, J [1 ]
ROBERTS, CJ [1 ]
TENDLER, SJB [1 ]
WILLIAMS, PM [1 ]
机构
[1] UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,BIOPHYS & SURFACE ANAL LAB,NOTTINGHAM NG7 2RD,ENGLAND
关键词
D O I
10.1021/j100029a036
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
A new in situ method of analyzing changes occurring to polymeric surfaces has been generated by the combination of atomic force microscopy (AFM) and surface plasmon resonance (SPR) in a novel instrument which can simultaneously acquire data from these two techniques. The application of this;instrument provides new insights into the dynamic changes occurring to a thin biodegradable polymer film when the surface of this film is exposed to a hydrolyzing environment. The AFM data enable the visualization of the topographical changes that result from degradation, whilst the SPR monitors the kinetics of the removal of polymer material from the film surface. The degradation of a spun cast thin film of a poly(ortho ester) is analyzed in this study. The,combined AFM/SPR data record the erosion of the thin film on the SPR sensor as degradation progresses. The pH sensitivity of the hydrolysis of the poly(ortho ester) film is explored by dynamically altering the pH during degradation to highlight the sensitivity of the instrument in the quantification of the degradation process.
引用
收藏
页码:11537 / 11542
页数:6
相关论文
共 23 条
  • [1] USE OF SCANNING PROBE MICROSCOPY AND SURFACE-PLASMON RESONANCE AS ANALYTICAL TOOLS IN THE STUDY OF ANTIBODY-COATED MICROTITER WELLS
    DAVIES, J
    ROBERTS, CJ
    DAWKES, AC
    SEFTON, J
    EDWARDS, JC
    GLASBEY, TO
    HAYMES, AG
    DAVIES, MC
    JACKSON, DE
    LOMAS, M
    SHAKESHEFF, KM
    TENDLER, SJB
    WILKINS, MJ
    WILLIAMS, PM
    [J]. LANGMUIR, 1994, 10 (08) : 2654 - 2661
  • [2] DAVIES J, 1994, NANOBIOLOGY, V3, P5
  • [3] THE ANALYSIS OF THE SURFACE CHEMICAL-STRUCTURE OF BIOMEDICAL ALIPHATIC POLYANHYDRIDES USING XPS AND TOF-SIMS
    DAVIES, MC
    KHAN, MA
    DOMB, A
    LANGER, R
    WATTS, JF
    PAUL, AJ
    [J]. JOURNAL OF APPLIED POLYMER SCIENCE, 1991, 42 (06) : 1597 - 1605
  • [4] DETERMINATION OF THICKNESS AND DIELECTRIC-CONSTANT OF THIN TRANSPARENT DIELECTRIC LAYERS USING SURFACE-PLASMON RESONANCE
    DEBRUIJN, HE
    ALTENBURG, BSF
    KOOYMAN, RPH
    GREVE, J
    [J]. OPTICS COMMUNICATIONS, 1991, 82 (5-6) : 425 - 432
  • [5] DOMB AJ, 1994, POLY BIOMATERIALS, P10016
  • [6] FLANAGAN MT, 1984, ELECTRON LETT, V20, P969
  • [7] THE INFLUENCE OF MICROSTRUCTURE AND MONOMER PROPERTIES ON THE EROSION MECHANISM OF A CLASS OF POLYANHYDRIDES
    GOPFERICH, A
    LANGER, R
    [J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1993, 31 (10) : 2445 - 2458
  • [8] HELLER J, 1985, Journal of Controlled Release, V2, P167, DOI 10.1016/0168-3659(85)90042-2
  • [9] POLYMERS FOR CONTROLLED PARENTERAL DELIVERY OF PEPTIDES AND PROTEINS
    HELLER, J
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 1993, 10 (2-3) : 163 - 204
  • [10] HELLER J, 1980, J POLYM SCI POL LETT, V18, P82