RESPONSE OF CANINE CEREBRAL-ARTERIES TO ENDOTHELIN-1

被引：9

作者：

GARCIA, JL ^{[1
]}

MONGE, L ^{[1
]}

GOMEZ, B ^{[1
]}

DIEGUEZ, G ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID, FAC MED, DEPT FISIOL, ARZOBISPO MORCILLO 1, E-28029 MADRID, SPAIN

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 04期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb06686.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of endothelin-1 (10(-10)-10(-7) M) were isometrically recorded in 4 mm cylindrical segments from the middle cerebral artery of dogs. Cumulative application of endothelin-1 produced marked, sustained contraction of arteries in a concentration-dependent-manner, the maximal response being about 2.6 times higher than that achieved with KCl (50 mM). The contraction by endothelin-1 was unaffected either by endothelium removal or by the cyclo-oxygenase inhibitors indomethacin (10(-6) M) and meclofenamate (10(-6) M). In a Ca2+-low (25-mu-M) solution the endothelin-1-induced arterial contraction was decreased. Therefore, the cerebral vasoconstriction induced by endothelin-1 could be caused by activation of specific receptors located on smooth muscle cells which would lead to the influx of extracellular calcium and vascular musculature contraction.

引用

页码：281 / 284

页数：4

共 28 条

[11] HEMODYNAMIC-EFFECTS OF ENDOTHELIN IN CONSCIOUS RATS [J].

HINOJOSALABORDE, C ;

OSBORN, JW ;

COWLEY, AW .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (06) :H1742-H1746

[12]

HOFFMAN A, 1989, LANCET, V2, P1519

[13] [I-125] ENDOTHELIN-1 BINDING-SITES - AUTORADIOGRAPHIC STUDIES IN THE BRAIN AND PERIPHERY OF VARIOUS SPECIES INCLUDING HUMANS [J].

HOYER, D ;

WAEBER, C ;

PALACIOS, JM .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1989, 13 :S162-S165

[14]

HUGHES A, 1988, BRIT J PHARMACOL, V85, pP722

[15] CLONING AND SEQUENCE-ANALYSIS OF CDNA-ENCODING THE PRECURSOR OF A HUMAN ENDOTHELIUM-DERIVED VASOCONSTRICTOR PEPTIDE, ENDOTHELIN - IDENTITY OF HUMAN AND PORCINE ENDOTHELIN [J].

ITOH, Y ;

YANAGISAWA, M ;

OHKUBO, S ;

KIMURA, C ;

KOSAKA, T ;

INOUE, A ;

ISHIDA, N ;

MITSUI, Y ;

ONDA, H ;

FUJINO, M ;

MASAKI, T .

FEBS LETTERS, 1988, 231 (02) :440-444

[16] MECHANISMS OF ACTION OF ENDOTHELIN ON ISOLATED FELINE CEREBRAL-ARTERIES - INVITRO PHARMACOLOGY AND ELECTROPHYSIOLOGY [J].

JANSEN, I ;

FALLGREN, B ;

EDVINSSON, L .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1989, 9 (06) :743-747

[17] CEREBRAL VASOSPASM FOLLOWING ANEURYSMAL SUBARACHNOID HEMORRHAGE [J].

KASSELL, NF ;

SASAKI, T ;

COLOHAN, ART ;

NAZAR, G .

STROKE, 1985, 16 (04) :562-572

[18] MECHANISM OF CONTRACTION TO ENDOTHELIN IN ISOLATED PORCINE CORONARY-ARTERY [J].

KASUYA, Y ;

ISHIKAWA, T ;

YANAGISAWA, M ;

KIMURA, S ;

GOTO, K ;

MASAKI, T .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (06) :H1828-H1835

[19] ENDOTHELIN - A POTENT RENAL AND SYSTEMIC VASOCONSTRICTOR PEPTIDE [J].

KING, AJ ;

BRENNER, BM ;

ANDERSON, S .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (06) :F1051-F1058

[20] EFFECTS OF ENDOTHELIN IN THE SYSTEMIC AND RENAL VASCULAR BEDS INVIVO [J].

LIPPTON, H ;

GOFF, J ;

HYMAN, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 155 (1-2) :197-199

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