RESPONSE OF CANINE CEREBRAL-ARTERIES TO ENDOTHELIN-1

被引：9

作者：

GARCIA, JL ^{[1
]}

MONGE, L ^{[1
]}

GOMEZ, B ^{[1
]}

DIEGUEZ, G ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID, FAC MED, DEPT FISIOL, ARZOBISPO MORCILLO 1, E-28029 MADRID, SPAIN

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 04期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb06686.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of endothelin-1 (10(-10)-10(-7) M) were isometrically recorded in 4 mm cylindrical segments from the middle cerebral artery of dogs. Cumulative application of endothelin-1 produced marked, sustained contraction of arteries in a concentration-dependent-manner, the maximal response being about 2.6 times higher than that achieved with KCl (50 mM). The contraction by endothelin-1 was unaffected either by endothelium removal or by the cyclo-oxygenase inhibitors indomethacin (10(-6) M) and meclofenamate (10(-6) M). In a Ca2+-low (25-mu-M) solution the endothelin-1-induced arterial contraction was decreased. Therefore, the cerebral vasoconstriction induced by endothelin-1 could be caused by activation of specific receptors located on smooth muscle cells which would lead to the influx of extracellular calcium and vascular musculature contraction.

引用

页码：281 / 284

页数：4

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