TOWARDS THE SYNTHESIS OF CALYCULIN - A SYNTHETIC INTERMEDIATE CORRESPONDING TO THE C(26)-C(37) FRAGMENT

被引：39

作者：

VACCARO, HA ^{[1
]}

LEVY, DE ^{[1
]}

SAWABE, A ^{[1
]}

JAETSCH, T ^{[1
]}

MASAMUNE, S ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 15期

关键词：

D O I：

10.1016/0040-4039(92)88107-G

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthetic intermediate 2 corresponding to the C(26)-C(37) fragment of calyculin A (1) has been synthesized. Key transformations include the efficient one-pot construction of the oxazole system embedded in 1 without epimerization-alpha [C(30)] to the ring, and the in situ formation of the dimethylamine by opening an N-methyllactam with Meerwein's reagent and trapping the resultant methylamine with formaldehyde.

引用

页码：1937 / 1940

页数：4

共 34 条

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