STRUCTURE-ACTIVITY-RELATIONSHIPS OF EPOXIDES - INDUCTION OF SISTER-CHROMATID EXCHANGES IN CHINESE-HAMSTER V79 CELLS

被引：19

作者：

VONDERHUDE, W

CARSTENSEN, S

OBE, G

机构：

[1] FREE UNIV BERLIN,INST ALLGEMEINE GENET,W-1000 BERLIN 33,GERMANY

[2] UNIV ESSEN GESAMTHSCH,FACHBEREICH GENET 9,W-4300 ESSEN 1,GERMANY

来源：

MUTATION RESEARCH | 1991年 / 249卷 / 01期

关键词：

STRUCTURE ACTIVITY RELATIONSHIP; EPOXIDES; SISTER-CHROMATID EXCHANGE; CHINESE HAMSTER V79 CELLS;

D O I：

10.1016/0027-5107(91)90132-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Analysis of SCE frequencies in Chinese hamster V79 cells was used to investigate structure-activity relationships of epoxides in mammalian cells. For this purpose the SCE-inducing potency of 58 epoxides was determined. Of these, 16 failed to induce SCE in V79 cells. According to the substitution of the oxirane ring the results show general agreement with results obtained in the Ames test. Mono-substituted epoxides had the highest genotoxic potency compared to di- and tri-substituted epoxides. In detail, there are differences in genotoxic potency between bacteria and mammalian cells which can be explained by differences in the cellular uptake of the compounds and by detoxification reactions.

引用

页码：55 / 70

页数：16

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