TOTAL SYNTHESIS AND ABSOLUTE-CONFIGURATION OF SPHINGOFUNGIN-D (N-ACETYL ASPERFUNGIN)

被引：22

作者：

CHIDA, N ^{[1
]}

IKEMOTO, H ^{[1
]}

NOGUCHI, A ^{[1
]}

AMANO, S ^{[1
]}

OGAWA, S ^{[1
]}

机构：

[1] KEIO UNIV,FAC SCI & TECHNOL,DEPT APPL CHEM,KOHOKU KU,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

NATURAL PRODUCT LETTERS | 1995年 / 6卷 / 04期

关键词：

SPHINGOFUNGINS; ASPERFUNGIN; ABSOLUTE CONFIGURATION; MYOINOSITOL; (R)-EPOXYOCTANE;

D O I：

10.1080/10575639508043174

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The total synthesis of an antifungal novel amino acid derivative, sphingofungin D (N-acetyl asperfungin) starting from myo-inositol and (R)-epoxyoctane is described. This synthetic study showed that the undetermined stereochemistry at C-14 in sphingofungins should be R.

引用

页码：295 / 302

页数：8

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