FIBROBLAST GROWTH-FACTORS IN MAMMALIAN DEVELOPMENT

被引：168

作者：

YAMAGUCHI, TP ^{[1
]}

ROSSANT, J ^{[1
]}

机构：

[1] UNIV TORONTO,TORONTO,ON,CANADA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 04期

关键词：

D O I：

10.1016/0959-437X(95)90053-J

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Polypeptide growth factors are secreted signalling molecules that function as intercellular communicators. Detailed analyses oi the expression and function of members of the fibroblast growth factor (FGF) family and their receptors have demonstrated that the FGF signalling pathways play essential roles in regulating cellular proliferation, differentiation and tissue patterning during vertebrate embryogenesis. Recent studies on the molecular basis of human dysmorphic syndromes have revealed that aberrant FGF signalling during limb and skeletal development can lead to pathogenesis.

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页码：485 / 491

页数：7

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