OLIGODEOXYNUCLEOTIDES CONTAINING 5-(1-PROPYNYL)-2'-DEOXYURIDINE FORMACETAL AND THIOFORMACETAL DIMER SYNTHONS

被引：19

作者：

LIN, KY

PUDLO, JS

JONES, RJ

BISCHOFBERGER, N

MATTEUCCI, MD

FROEHLER, BC

机构：

[1] Gilead Sciences, Inc., Foster City, CA 94404

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(01)80681-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oligodeoxynucleotides containing the C-5 propyne 2'-deoxyuridine analog in conjunction with the formacetal and 5'-thioformacetal linkage are described. Thermal denaturation analysis demonstrates that these analogs have enhanced binding affinity to both single-strand RNA and DNA and double-strand DNA.

引用

页码：1061 / 1064

页数：4

共 17 条

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