ANXIOLYTIC EFFECT OF CCK-ANTAGONISTS ON PLUS-MAZE BEHAVIOR IN MICE

被引：73

作者：

RATAUD, J ^{[1
]}

DARCHE, F ^{[1
]}

PIOT, O ^{[1
]}

STUTZMANN, JM ^{[1
]}

BOHME, GA ^{[1
]}

BLANCHARD, JC ^{[1
]}

机构：

[1] RHONE POULENC SANTE,CTR RECH VITRY ALFORTVILLE,DEPT BIOL,13 QUAI JULES GUESDE,F-94403 VITRY,FRANCE

来源：

BRAIN RESEARCH | 1991年 / 548卷 / 1-2期

关键词：

ANXIETY; PLUS-MAZE TEST IN MICE; BEHAVIORAL STUDY; CHOLECYSTOKININ ANTAGONIST; CCK-A RECEPTOR; CCK-B RECEPTOR;

D O I：

10.1016/0006-8993(91)91139-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of systemic treatment with the CCK-B receptor antagonist L-365,260, its 3S-(-) enantiomer and the CCK-A receptor antagonist devazepide were assessed in the plus-maze procedure in mice. L-365,260 (1-1000-mu-g.kg-1 i.p.) produced a dose-dependent increase in the percentage of entries into, and the percentage of time spent in the open arms. Total arm entry was not consistently modified. Neither the 3S-(-) enantiomer of L-365,260 nor devazepide (both administered at 100-10.000-mu-g.kg-1) enhanced the exploratory behavior of mice. These results suggest that CCK-B, rather than CCK-A antagonists may possess 'anxiolytic' properties in mice.

引用

页码：315 / 317

页数：3

共 16 条

[1] ABELSON JL, 1990, ARCH GEN PSYCHIAT, V47, P395
[2] BENZODIAZEPINE GASTRIN AND BRAIN CHOLECYSTOKININ RECEPTOR LIGANDS - L-365,260
BOCK, MG
DIPARDO, RM
EVANS, BE
RITTLE, KE
WHITTER, WL
VEBER, DF
ANDERSON, PS
FREIDINGER, RM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (01) : 13 - 16
[3] CHOLECYSTOKININ-TETRAPEPTIDE INDUCES PANIC ATTACKS IN PATIENTS WITH PANIC DISORDER
BRADWEJN, J
KOSZYCKI, D
METERISSIAN, G
[J]. CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 1990, 35 (01): : 83 - 85
[4] BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION OF AN EXTREMELY POTENT AND SELECTIVE NONPEPTIDE CHOLECYSTOKININ ANTAGONIST
CHANG, RSL
LOTTI, VJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (13) : 4923 - 4926
[5] CRAWLEY JN, 1988, ISI ATLAS-PHARMACOL, V2, P84
[6] CCK8 EFFECTS ON MOTIVATIONAL AND EMOTIONAL STATES OF RATS INVOLVE CCKA RECEPTORS OF THE POSTERO-MEDIAN PART OF THE NUCLEUS ACCUMBENS
DAUGE, V
STEIMES, P
DERRIEN, M
BEAU, N
ROQUES, BP
FEGER, J
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 34 (01) : 157 - 163
[7] INVESTIGATION OF BEHAVIORAL AND ELECTROPHYSIOLOGICAL RESPONSES INDUCED BY SELECTIVE STIMULATION OF CCKB RECEPTORS BY USING A NEW HIGHLY POTENT CCK ANALOG, BC-264
DAUGE, V
BOHME, GA
CRAWLEY, JN
DURIEUX, C
STUTZMANN, JM
FEGER, J
BLANCHARD, JC
ROQUES, BP
[J]. SYNAPSE, 1990, 6 (01) : 73 - 80
[8] DEMONTIGNY C, 1989, ARCH GEN PSYCHIAT, V46, P511
[9] HARRO J, 1990, N-S ARCH PHARMACOL, V341, P62
[10] DEVELOPMENT OF A CLASS OF SELECTIVE CHOLECYSTOKININ TYPE-B RECEPTOR ANTAGONISTS HAVING POTENT ANXIOLYTIC ACTIVITY
HUGHES, J
BODEN, P
COSTALL, B
DOMENEY, A
KELLY, E
HORWELL, DC
HUNTER, JC
PINNOCK, RD
WOODRUFF, GN
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) : 6728 - 6732

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