SERUM CONCENTRATIONS OF VON-WILLEBRAND-FACTOR AND SOLUBLE THROMBOMODULIN INDICATE ALTERATION OF ENDOTHELIAL FUNCTION IN INFLAMMATORY BOWEL DISEASES

被引：21

作者：

SAWYERR, AM

SMITH, MS

HALL, A

HUDSON, M

HAY, CR

WAKEFIELD, AJ

BROOK, MG

TOMURA, H

POUNDER, RE

机构：

[1] UNIV LONDON,ROYAL FREE HOSP & SCH MED,DEPT MED,LONDON NW3 2QG,ENGLAND

[2] UNIV LONDON,ROYAL FREE HOSP & SCH MED,DEPT INFECT DIS,LONDON NW3 2QG,ENGLAND

[3] UNIV LIVERPOOL,ROYAL LIVERPOOL HOSP,DEPT HAEMATOL,LIVERPOOL L7 8XP,MERSEYSIDE,ENGLAND

[4] FUJI CHEM IND CO LTD,TOYAMA,JAPAN

来源：

DIGESTIVE DISEASES AND SCIENCES | 1995年 / 40卷 / 04期

基金：

英国惠康基金;

关键词：

INFLAMMATORY BOWEL DISEASES; CROHNS DISEASE; ULCERATIVE COLITIS; VON WILLEBRAND FACTOR; THROMBOMODULIN; ENDOTHELIUM; VASCULITIS; ACUTE-PHASE RESPONSE;

D O I：

10.1007/BF02064981

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Serum concentrations of immunoreactive von Willebrand factor (VWF) and soluble thrombomodulin (TM), and vWF multimer patterns were measured to assess endothelial function in patients with inflammatory intestinal diseases. In Crohn's disease and acute infective diarrhea, vWF concentrations were significantly higher than in normal controls. In all patient groups, multimeric analysis of vWF and the concentration of serum TM were not different from normal controls. The results indicate alteration of endothelial function in inflammatory intestinal disorders. They may be compatible with the presence of localized vasculitis, but indicate that systemic endothelial destruction does not occur in inflammatory bowel disease.

引用

页码：793 / 799

页数：7

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