SERUM CONCENTRATIONS OF VON-WILLEBRAND-FACTOR AND SOLUBLE THROMBOMODULIN INDICATE ALTERATION OF ENDOTHELIAL FUNCTION IN INFLAMMATORY BOWEL DISEASES

被引:21
作者
SAWYERR, AM
SMITH, MS
HALL, A
HUDSON, M
HAY, CR
WAKEFIELD, AJ
BROOK, MG
TOMURA, H
POUNDER, RE
机构
[1] UNIV LONDON,ROYAL FREE HOSP & SCH MED,DEPT MED,LONDON NW3 2QG,ENGLAND
[2] UNIV LONDON,ROYAL FREE HOSP & SCH MED,DEPT INFECT DIS,LONDON NW3 2QG,ENGLAND
[3] UNIV LIVERPOOL,ROYAL LIVERPOOL HOSP,DEPT HAEMATOL,LIVERPOOL L7 8XP,MERSEYSIDE,ENGLAND
[4] FUJI CHEM IND CO LTD,TOYAMA,JAPAN
基金
英国惠康基金;
关键词
INFLAMMATORY BOWEL DISEASES; CROHNS DISEASE; ULCERATIVE COLITIS; VON WILLEBRAND FACTOR; THROMBOMODULIN; ENDOTHELIUM; VASCULITIS; ACUTE-PHASE RESPONSE;
D O I
10.1007/BF02064981
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Serum concentrations of immunoreactive von Willebrand factor (VWF) and soluble thrombomodulin (TM), and vWF multimer patterns were measured to assess endothelial function in patients with inflammatory intestinal diseases. In Crohn's disease and acute infective diarrhea, vWF concentrations were significantly higher than in normal controls. In all patient groups, multimeric analysis of vWF and the concentration of serum TM were not different from normal controls. The results indicate alteration of endothelial function in inflammatory intestinal disorders. They may be compatible with the presence of localized vasculitis, but indicate that systemic endothelial destruction does not occur in inflammatory bowel disease.
引用
收藏
页码:793 / 799
页数:7
相关论文
共 46 条
[21]   VASCULAR CHANGES IN CROHNS DISEASE [J].
KNUTSON, H ;
LUNDERQU.A .
AMERICAN JOURNAL OF ROENTGENOLOGY RADIUM THERAPY AND NUCLEAR MEDICINE, 1968, 103 (02) :380-&
[22]   ONE-STEP SANDWICH ENZYME-IMMUNOASSAY FOR SOLUBLE HUMAN THROMBOMODULIN USING MONOCLONAL-ANTIBODIES [J].
KODAMA, S ;
UCHIJIMA, E ;
NAGAI, M ;
MIKAWATANI, K ;
HAYASHI, T ;
SUZUKI, K .
CLINICA CHIMICA ACTA, 1990, 192 (03) :191-200
[23]   CROHNS DISEASE (REGIONAL ENTERITIS) OF THE LARGE INTESTINE AND ITS DISTINCTION FROM ULCERATIVE COLITIS [J].
LOCKHARTMUMMERY, HE ;
MORSON, BC .
GUT, 1960, 1 (02) :87-105
[24]   ALTERATIONS OF FACTOR-VIII VON WILLEBRAND FACTOR IN CLINICAL CONDITIONS ASSOCIATED WITH AN INCREASE IN ITS PLASMA-CONCENTRATION [J].
LOMBARDI, R ;
MANNUCCI, PM ;
SEGHATCHIAN, MJ ;
GARCIA, VV ;
COPPOLA, R .
BRITISH JOURNAL OF HAEMATOLOGY, 1981, 49 (01) :61-68
[25]   THROMBOMODULIN IS FOUND ON ENDOTHELIUM OF ARTERIES, VEINS, CAPILLARIES, AND LYMPHATICS, AND ON SYNCYTIOTROPHOBLAST OF HUMAN-PLACENTA [J].
MARUYAMA, I ;
BELL, CE ;
MAJERUS, PW .
JOURNAL OF CELL BIOLOGY, 1985, 101 (02) :363-371
[26]   CROHNS DISEASE OF COLON [J].
MCGOVERN, VJ ;
GOULSTON, SJ .
GUT, 1968, 9 (02) :164-&
[27]   ENDOTOXIN ENHANCES TISSUE FACTOR AND SUPPRESSES THROMBOMODULIN EXPRESSION OF HUMAN VASCULAR ENDOTHELIUM INVITRO [J].
MOORE, KL ;
ANDREOLI, SP ;
ESMON, NL ;
ESMON, CT ;
BANG, NU .
JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (01) :124-130
[28]   MODULATION OF ENDOTHELIAL-CELL HEMOSTATIC PROPERTIES BY TUMOR-NECROSIS-FACTOR [J].
NAWROTH, PP ;
STERN, DM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 163 (03) :740-745
[29]   INTERLEUKIN-1 INDUCES ENDOTHELIAL-CELL PROCOAGULANT WHILE SUPPRESSING CELL-SURFACE ANTICOAGULANT ACTIVITY [J].
NAWROTH, PP ;
HANDLEY, DA ;
ESMON, CT ;
STERN, DM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (10) :3460-3464
[30]  
PALEOLOG EM, 1990, BLOOD, V75, P688