Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications

被引：75

作者：

Enfield, Katey S. S. ^{[1
,2
]}

Pikor, Larissa A. ^{[1
,2
]}

Martinez, Victor D. ^{[1
,3
]}

Lam, Wan L. ^{[1
,2
,3
]}

机构：

[1] British Columbia Canc Res Ctr, Vancouver, BC V5Z IL3, Canada

[2] Univ British Columbia, Interdisciplinary Oncol Program, Vancouver, BC V5Z 1L3, Canada

[3] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V6T 2B5, Canada

来源：

GENETICS RESEARCH INTERNATIONAL | 2012年 / 2012卷

关键词：

D O I：

10.1155/2012/737416

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lung cancer biology has traditionally focused on genomic and epigenomic deregulation of protein-coding genes to identify oncogenes and tumor suppressors diagnostic and therapeutic targets. Another important layer of cancer biology has emerged in the form of noncoding RNAs (ncRNAs), which are major regulators of key cellular processes such as proliferation, RNA splicing, gene regulation, and apoptosis. In the past decade, microRNAs (miRNAs) have moved to the forefront of ncRNA cancer research, while the role of long noncoding RNAs (lncRNAs) is emerging. Here we review the mechanisms by which miRNAs and lncRNAs are deregulated in lung cancer, the technologies that can be applied to detect such alterations, and the clinical potential of these RNA species. An improved comprehension of lung cancer biology will come through the understanding of the interplay between deregulation of non-coding RNAs, the protein-coding genes they regulate, and how these interactions influence cellular networks and signalling pathways.

引用

页数：16

共 188 条

[1] Computational prediction of miRNAs in Arabidopsis thaliana [J].

Adai, A ;

Johnson, C ;

Mlotshwa, S ;

Archer-Evans, S ;

Manocha, V ;

Vance, V ;

Sundaresan, V .

GENOME RESEARCH, 2005, 15 (01) :78-91

[2] Subtle variations in Pten dose determine cancer susceptibility [J].

Alimonti, Andrea ;

Carracedo, Arkaitz ;

Clohessy, John G. ;

Trotman, Lloyd C. ;

Nardella, Caterina ;

Egia, Ainara ;

Salmena, Leonardo ;

Sampieri, Katia ;

Haveman, William J. ;

Brogi, Edi ;

Richardson, Andrea L. ;

Zhang, Jiangwen ;

Pandolfi, Pier Paolo .

NATURE GENETICS, 2010, 42 (05) :454-U136

[3] The Promise of MicroRNA Replacement Therapy [J].

Bader, Andreas G. ;

Brown, David ;

Winkler, Matthew .

CANCER RESEARCH, 2010, 70 (18) :7027-7030

[4] The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis [J].

Barsyte-Lovejoy, Dalia ;

Lau, Suzanne K. ;

Boutros, Paul C. ;

Khosravi, Fereshteh ;

Jurisica, Igor ;

Andrulis, Irene L. ;

Tsao, Ming S. ;

Penn, Linda Z. .

CANCER RESEARCH, 2006, 66 (10) :5330-5337

[5] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[6] Characterizing the Impact of Smoking and Lung Cancer on the Airway Transcriptome Using RNA-Seq [J].

Beane, Jennifer ;

Vick, Jessica ;

Schembri, Frank ;

Anderlind, Christina ;

Gower, Adam ;

Campbell, Joshua ;

Luo, Lingqi ;

Zhang, Xiao Hui ;

Xiao, Ji ;

Alekseyev, Yuriy O. ;

Wang, Shenglong ;

Levy, Shawn ;

Massion, Pierre P. ;

Lenburg, Marc ;

Spira, Avrum .

CANCER PREVENTION RESEARCH, 2011, 4 (06) :803-817

[7] 3′-End Sequencing for Expression Quantification (3SEQ) from Archival Tumor Samples [J].

Beck, Andrew H. ;

Weng, Ziming ;

Witten, Daniela M. ;

Zhu, Shirley ;

Foley, Joseph W. ;

Lacroute, Phil ;

Smith, Cheryl L. ;

Tibshirani, Robert ;

van de Rijn, Matt ;

Sidow, Arend ;

West, Robert B. .

PLOS ONE, 2010, 5 (01)

[8] The microRNA.org resource: targets and expression [J].

Betel, Doron ;

Wilson, Manda ;

Gabow, Aaron ;

Marks, Debora S. ;

Sander, Chris .

NUCLEIC ACIDS RESEARCH, 2008, 36 :D149-D153

[9] Deletions involving long-range conserved nongenic sequences upstream and downstream of FOXL2 as a novel disease-causing mechanism in Blepharophimosis syndrome [J].

Beysen, D ;

Raes, J ;

Leroy, BP ;

Lucassen, A ;

Yates, JRW ;

Clayton-Smith, J ;

Ilyina, H ;

Brooks, SS ;

Christin-Maitre, S ;

Fellous, M ;

Fryns, JP ;

Kim, JR ;

Lapunzina, P ;

Lemyre, E ;

Meire, F ;

Messiaen, LM ;

Oley, C ;

Splitt, M ;

Thomson, J ;

Van de Peer, Y ;

Veitia, RA ;

De Paepe, A ;

De Baere, E .

AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 77 (02) :205-218

[10] Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project [J].

Birney, Ewan ;

Stamatoyannopoulos, John A. ;

Dutta, Anindya ;

Guigo, Roderic ;

Gingeras, Thomas R. ;

Margulies, Elliott H. ;

Weng, Zhiping ;

Snyder, Michael ;

Dermitzakis, Emmanouil T. ;

Stamatoyannopoulos, John A. ;

Thurman, Robert E. ;

Kuehn, Michael S. ;

Taylor, Christopher M. ;

Neph, Shane ;

Koch, Christoph M. ;

Asthana, Saurabh ;

Malhotra, Ankit ;

Adzhubei, Ivan ;

Greenbaum, Jason A. ;

Andrews, Robert M. ;

Flicek, Paul ;

Boyle, Patrick J. ;

Cao, Hua ;

Carter, Nigel P. ;

Clelland, Gayle K. ;

Davis, Sean ;

Day, Nathan ;

Dhami, Pawandeep ;

Dillon, Shane C. ;

Dorschner, Michael O. ;

Fiegler, Heike ;

Giresi, Paul G. ;

Goldy, Jeff ;

Hawrylycz, Michael ;

Haydock, Andrew ;

Humbert, Richard ;

James, Keith D. ;

Johnson, Brett E. ;

Johnson, Ericka M. ;

Frum, Tristan T. ;

Rosenzweig, Elizabeth R. ;

Karnani, Neerja ;

Lee, Kirsten ;

Lefebvre, Gregory C. ;

Navas, Patrick A. ;

Neri, Fidencio ;

Parker, Stephen C. J. ;

Sabo, Peter J. ;

Sandstrom, Richard ;

Shafer, Anthony .

NATURE, 2007, 447 (7146) :799-816

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