SYNTHESIS AND ANTIRHINOVIRUS ACTIVITY OF 8-SUBSTITUTED ANALOGS OF 6-(DIMETHYLAMINO)-9-(4-METHYLBENZYL)-2-(TRIFLUOROMETHYL)-9H-PURINE

被引：16

作者：

KELLEY, JL ^{[1
]}

LINN, JA ^{[1
]}

SELWAY, JWT ^{[1
]}

机构：

[1] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 01期

关键词：

D O I：

10.1021/jm00105a023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several 8-substituted analogues of 6-(dimethylamino)-9-(4-methylbenzyl)-2-(trifluoromethyl)-9H-purine (1) were synthesized and tested for activity against rhinovirus type 1B. Among 16 8-substituted analogues, the 8-amino (3) and 8-bromo (2) analogues were most active with IC50s of 0.36 and 1.4-mu-M, respectively, under conditions where 1 had an IC50 of 0.03-mu-M.

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页码：157 / 160

页数：4

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