EXPOSURE OF CHO CELLS TO ALUI - COMPARISON OF CHROMOSOMAL-ABERRATIONS AND CELL-SURVIVAL

被引：6

作者：

OBE, G

EKE, P

JOHANNES, C

机构：

[1] University GH Essen, Department of Genetics, D-45117 Essen

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1995年 / 326卷 / 02期

关键词：

ALUI; CHROMOSOME ABERRATION; COLONY-FORMING ABILITY;

D O I：

10.1016/0027-5107(94)00169-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chinese hamster ovary (CHO) cells were exposed to various doses of the restriction endonuclease AluI in the presence of 2.2 M glycerol. Some of the cells were cultured for analysis of chromosomal aberrations and some for analysis of colony-forming ability. Cell killing is mainly mediated by chromosomal aberrations.

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页码：171 / 174

页数：4

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