SYNTHESIS AND EVALUATION OF NEW 2',3'-DIDEOXYNUCLEOSIDE ANALOGS AS POTENTIAL ANTI-AIDS AND ANTIHERPES DRUGS

被引：6

作者：

FARAJ, A

MAILLARD, M

LEMAITRE, M

LETELLIER, S

FRAPPIER, F

FLORENT, JC

GRIERSON, DS

MONNERET, C

ZERIAL, A

机构：

[1] FAC SCI PHARMACEUT & BIOL PARIS,UA 484,4 AVE OBSERV,F-75005 PARIS,FRANCE

[2] RHONE POULENC RORER RECH DEV,F-94403 VITRY,FRANCE

[3] CNRS,INST CHIM SUBST NAT,F-91190 GIF SUR YVETTE,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 27卷 / 02期

关键词：

ANTI-HERPES DRUG; 2'; 3'-DIDEOXYNUCLEOSIDE ANALOG; ANTI-HIV;

D O I：

10.1016/0223-5234(92)90102-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based on the known structure-activity relationships for the active anti-HIV, a series of 3'-deoxy-3'-N-functionalized thymidine analogs has been synthesized from thymidine. Evaluation for inhibitory activity against human immunodeficiency virus (HIV) replication in CEM cells and against herpes simplex virus in MRC-5 cells is reported.

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收藏

页码：141 / 148

页数：8

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