SCATTER FACTOR/HEPATOCYTE GROWTH-FACTOR IS ESSENTIAL FOR LIVER DEVELOPMENT

被引：1161

作者：

SCHMIDT, C

BLADT, F

GOEDECKE, S

BRINKMANN, V

ZSCHIESCHE, W

SHARPE, M

GHERARDI, E

BIRCHMEIER, C

机构：

[1] MAX PLANCK GESELL,MAX DELBRUCK LAB,D-50829 COLOGNE,GERMANY

[2] MAX DELBRUCK CTR MOLEC MED,D-13122 BERLIN,GERMANY

[3] UNIV CAMBRIDGE,SCH MED,MRC CTR,ICRF,CELL INTERACT LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

NATURE | 1995年 / 373卷 / 6516期

关键词：

D O I：

10.1038/373699a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

POLYPEPTIDE growth factors are important effecters of cell growth and differentiation in vitro and are thought to be critical for processes such as specification of cell fate, tissue growth and organogenesis in vivo, Scatter factor(1-3)/hepatocyte growth factor(4,5) (SF/HGF) is the prototype of an emerging family of growth factors that resemble in their domain structure and mechanism of activation the blood proteinase plasminogen(6,7). The cellular responses of SF/HGF are mediated by the c-Met tyrosine kinase receptor(8-10). Here we report that mice lacking SF/HGF fail to complete development and die in utero. The mutation affects the embryonic liver, which is reduced in size and shows extensive loss of parenchymal cells, In addition, development of the placenta, particularly of trophoblast cells, is impaired. Thus, SF/HGF is essential for the development of several epithelial organs.

引用

页码：699 / 702

页数：4

共 29 条

[11] A FUNCTIONAL DOMAIN IN THE HEAVY-CHAIN OF SCATTER FACTOR HEPATOCYTE GROWTH-FACTOR BINDS THE C-MET RECEPTOR AND INDUCES CELL-DISSOCIATION BUT NOT MITOGENESIS [J].