A NEW SYNTHESIS OF THE POTENT AND SELECTIVE ANTI-HERPESVIRUS AGENT (S)-1-[3-HYDROXY-2-(PHOSPHONYLMETHOXY)PROPYL]CYTOSINE

被引：17

作者：

BRONSON, JJ ^{[1
]}

FERRARA, LM ^{[1
]}

HOWELL, HG ^{[1
]}

BRODFUEHRER, PR ^{[1
]}

MARTIN, JC ^{[1
]}

机构：

[1] CHEM PROC DEV DEPT, SYRACUSE, NY 13221 USA

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1990年 / 9卷 / 06期

关键词：

D O I：

10.1080/15257779008043142

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new synthetic approach to (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (3, (S)-HPMPC) is based on coupling of the heterocyclic moiety with a glycerol-derived side chain, followed by introduction of the phosphonylmethyl ether group. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：745 / 769

页数：25

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