ABSOLUTE-CONFIGURATION OF TAUTOMYCIN, A PROTEIN PHOSPHATASE INHIBITOR FROM A STREPTOMYCETE

被引：58

作者：

UBUKATA, M

CHENG, XC

ISOBE, M

ISONO, K

机构：

[1] NAGOYA UNIV, SCH AGR, NAGOYA 46401, JAPAN

[2] TOKAI UNIV, SCH MARINE SCI & TECHNOL, SHIMIZU, SHIZUOKA 424, JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 05期

关键词：

D O I：

10.1039/p19930000617

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The absolute configurations of all the chiral centres of tautomycin, a new protein phosphatase inhibitor from Streptomyces spiroverticillatus, have been determined. Because of its non-crystallinity and flexibility, the absolute configurations of tautomycin, which possesses 13 chiral centres were determined on the basis of chemical degradation and spectroscopic evidence, with aid from conformational calculations.

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页码：617 / 624

页数：8

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