PHYSICAL FACTORS INVOLVED IN STRESS-WAVE-INDUCED CELL INJURY - THE EFFECT OF STRESS GRADIENT

被引：71

作者：

DOUKAS, AG ^{[1
]}

MCAULIFFE, DJ ^{[1
]}

LEE, S ^{[1
]}

VENUGOPALAN, V ^{[1
]}

FLOTTE, TJ ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT DERMATOL,BOSTON,MA 02115

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 1995年 / 21卷 / 07期

关键词：

ABLATION; PHOTOACOUSTICS; SHOCK WAVES; STRESS GRADIENT; CELL VIABILITY; MEMBRANE PERMEABILITY;

D O I：

10.1016/0301-5629(95)00027-O

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

We have studied the biological effects of ablation-induced stress waves in vitro. Mouse breast sarcoma cells (EMT-6) were exposed to stress waves that differed only in rise time, Two assays were used to determine cell injury: incorporation of tritiated thymidine (viability assay), and transmission electron microscopy (morphology assay), We present evidence that the rise time of stress waves can significantly modify cell viability and that cell injury correlates better with the stress gradient than peak stress.

引用

页码：961 / 967

页数：7

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