URINARY-EXCRETION RATE OF ENDOTHELIN-1 IN PATIENTS WITH ESSENTIAL-HYPERTENSION AND SALT SENSITIVITY

被引:65
作者
HOFFMAN, A
GROSSMAN, E
GOLDSTEIN, DS
GILL, JR
KEISER, HR
机构
[1] TECHNION ISRAEL INST TECHNOL,HAIFA,ISRAEL
[2] NHLBI,HYPERTENS ENDOCRINE BRANCH,BETHESDA,MD 20892
关键词
D O I
10.1038/ki.1994.72
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
To assess the possible role of ET-1 in the pathogenesis of hypertension and salt sensitivity levels of immunoreactive endothelin-1 (irET-1) were measured in plasma and urine of 17 patients with essential hypertension and in 19 normotensive control subjects. Effects of alterations in dietary sodium content on urinary irET-1 levels also were assessed. Plasma levels of irET-1 did not differ between the hypertensives and normotensive groups (1.1 +/- 0.3 and 1.3 +/- 0.1 pg/ml). Urine samples of both groups contained high concentrations of irET-1. However, the mean daily urinary excretion of irET-1 in the hypertensives was less than one-third that in controls (29 +/- 3 vs. 109 +/- 21 ng/day, respectively, P < 0.01). Changing dietary sodium content in the hypertensives had no effect on mean irET-1 excretion. However, on either low, intermediate, or high salt diet, ''salt sensitive'' hypertensives had lower levels of the peptide than ''salt resistant'' patients (23 +/- 3 vs. 36 +/- 5 ng/day, respectively, P < 0.05). The data demonstrate a marked reduction in irET-1 excretion in patients with essential hypertension, despite normal plasma levels of the peptide. Since ET-1 has diuretic and natriuretic properties, the decreased renal excretion of ET-1 may be of relevance to the pathophysiology of hypertension and salt sensitivity.
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页码:556 / 560
页数:5
相关论文
共 22 条
[1]   ENDOTHELIN-1-LIKE IMMUNOREACTIVITY IN HUMAN URINE [J].
ANDO, K ;
HIRATA, Y ;
TAKEI, Y ;
KAWAKAMI, M ;
MARUMO, F .
NEPHRON, 1991, 57 (01) :36-39
[2]  
BENIGNI A, 1990, J AM SOC NEPHROL, V1, P411
[3]  
BERBINSCHI A, 1989, LANCET, V2, P46
[4]   A SENSITIVE RADIOIMMUNOASSAY MEASURING ENDOTHELIN-LIKE IMMUNOREACTIVITY IN HUMAN PLASMA - COMPARISON OF LEVELS IN PATIENTS WITH ESSENTIAL-HYPERTENSION AND NORMOTENSIVE CONTROL SUBJECTS [J].
DAVENPORT, AP ;
ASHBY, MJ ;
EASTON, P ;
ELLA, S ;
BEDFORD, J ;
DICKERSON, C ;
NUNEZ, DJ ;
CAPPER, SJ ;
BROWN, MJ .
CLINICAL SCIENCE, 1990, 78 (03) :261-264
[5]   PLASMA AND URINARY CATECHOLAMINES IN SALT-SENSITIVE IDIOPATHIC HYPERTENSION [J].
GILL, JR ;
GULLNER, HG ;
LAKE, CR ;
LAKATUA, DJ ;
LAN, G .
HYPERTENSION, 1988, 11 (04) :312-319
[6]   SODIUM-INTAKE MODULATES RENAL VASCULAR REACTIVITY TO ENDOTHELIN-1 IN DAHL RATS [J].
GROSSMAN, E ;
HOFFMAN, A ;
KEISER, HR .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1990, 17 (02) :121-128
[7]   ENDOTHELIN INDUCES AN INITIAL INCREASE IN CARDIAC-OUTPUT ASSOCIATED WITH SELECTIVE VASODILATION IN RATS [J].
HOFFMAN, A ;
GROSSMAN, E ;
OHMAN, KP ;
MARKS, E ;
KEISER, HR .
LIFE SCIENCES, 1989, 45 (03) :249-255
[8]   OPPOSITE EFFECTS OF ENDOTHELIN-1 AND BIG-ENDOTHELIN-(1-39) ON RENAL-FUNCTION IN RATS [J].
HOFFMAN, A ;
GROSSMAN, E ;
KEISER, HR .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 182 (03) :603-606
[9]  
HOFFMAN A, 1989, LANCET, V2, P1519
[10]   ALTERATIONS IN RENAL ENDOTHELIN-1 PRODUCTION IN THE SPONTANEOUSLY HYPERTENSIVE RAT [J].
HUGHES, AK ;
CLINE, RC ;
KOHAN, DE .
HYPERTENSION, 1992, 20 (05) :666-673