SYNTHESIS AND ANTITUMOR PROPERTIES OF SOME NEUTRAL TRIESTERS OF 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE AND 3',5'-CYCLIC-MONOPHOSPHATE

被引:7
作者
GIRARDET, JL
GOSSELIN, G
PERIGAUD, C
BALZARINI, J
DECLERCQ, E
IMBACH, JL
机构
[1] UNIV MONTPELLIER 2,CHIM BIOORGAN LAB,CNRS,URA 488,F-34095 MONTPELLIER 5,FRANCE
[2] KATHOLIEKE UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM
来源
NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期
关键词
D O I
10.1080/15257779508012442
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Several new prodrugs of 5-fluoro-2'-deoxyuridine 5'-monophosphate and 3',5'-cyclic monophosphate were synthesized and their antitumor activities were evaluated in vitro.
引用
收藏
页码:645 / 647
页数:3
相关论文
共 3 条
[1]   5-SUBSTITUTED 2'-DEOXYURIDINES - CORRELATION BETWEEN INHIBITION OF TUMOR-CELL GROWTH AND INHIBITION OF THYMIDINE KINASE AND THYMIDYLATE SYNTHETASE [J].
BALZARINI, J ;
DECLERCQ, E ;
MERTES, MP ;
SHUGAR, D ;
TORRENCE, PF .
BIOCHEMICAL PHARMACOLOGY, 1982, 31 (22) :3673-3682
[2]   RATIONAL DESIGN FOR CYTOSOLIC DELIVERY OF NUCLEOSIDE MONOPHOSPHATES - SATE AND DTE AS ENZYME-LABILE TRANSIENT PHOSPHATE PROTECTING GROUPS [J].
PERIGAUD, C ;
GOSSELIN, G ;
LEFEBVRE, I ;
GIRARDET, JL ;
BENZARIA, S ;
BARBER, I ;
IMBACH, JL .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (12) :2521-2526
[3]   INTRACELLULAR DELIVERY OF NUCLEOSIDE MONOPHOSPHATES THROUGH A REDUCTASE-MEDIATED ACTIVATION PROCESS [J].
PUECH, F ;
GOSSELIN, G ;
LEFEBVRE, I ;
POMPON, A ;
AUBERTIN, AM ;
KIRN, A ;
IMBACH, JL .
ANTIVIRAL RESEARCH, 1993, 22 (2-3) :155-174