CEREBRAL PHARMACODYNAMICS OF PHYSOSTIGMINE IN ALZHEIMERS-DISEASE INVESTIGATED USING SINGLE-PHOTON COMPUTERIZED-TOMOGRAPHY

被引：51

作者：

HUNTER, R

WYPER, DJ

PATTERSON, J

HANSEN, MT

GOODWIN, GM

机构：

[1] ROYAL EDINBURGH & ASSOC HOSP,MRC,BRAIN METAB UNIT,MORNINGSIDE PK,EDINBURGH EH8 9JZ,SCOTLAND

[2] SO GEN HOSP,INST NEUROL SCI,DEPT CLIN PHYS,WELLCOME NEUROSCI GRP,GLASGOW G51 4TF,SCOTLAND

来源：

BRITISH JOURNAL OF PSYCHIATRY | 1991年 / 158卷

基金：

英国惠康基金;

关键词：

D O I：

10.1192/bjp.158.3.351

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The effects of physostigmine on patterns of rCBF in patients with pre-senile Alzheimer's disease were studied using 99m Tc-labelled HMPAO SPECT. Regional CBF increased in the left cortex relative to right, with the most significant effect in left frontal and higher frontal regions. Measures of regional brain function, such as SPECT, are an important complement to psychological test batteries in understanding the effects in brain of putative antidementia drugs. SPECT brain imaging could extend our understanding of the action of psychotropic drugs in other major psychiatric illnesses.

引用

页码：351 / 357

页数：7

共 45 条

[1] CHOLINE-ACETYLTRANSFERASE (CHAT) ACTIVITY DIFFERS IN RIGHT AND LEFT HUMAN TEMPORAL LOBES [J].