GERI-BP001 COMPOUNDS, NEW INHIBITORS OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE FROM ASPERGILLUS-FUMIGATUS F37 .1. PRODUCTION, ISOLATION, AND PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

被引：24

作者：

JEONG, TS

KIM, SU

SON, KH

KWON, BM

KIM, YK

CHOI, MU

BOK, SH

机构：

[1] KIST,KOREA RES INST BIOSCI & BIOTECHNOL,BIOPROD RES GRP,TAEJON 305600,SOUTH KOREA

[2] SEOUL NATL UNIV,COLL NAT SCI,DEPT CHEM,SEOUL 151742,SOUTH KOREA

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 08期

关键词：

D O I：

10.7164/antibiotics.48.751

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

GERI-BP001 compounds, new inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT), were isolated from a culture broth of Aspergillus fumigatus F37 by acetone extraction, EtOAc extraction, SiO2 column chromatography, and reverse phase HPLC. GERI-BP001 M, A, and B inhibit ACAT activity in an enzyme assay system using rat liver microsomes by 50% at concentrations of 42, 94, and 40 mu M, respectively.

引用

页码：751 / 756

页数：6

共 13 条

[1] PROPERTIES OF ACYL-COA-CHOLESTEROL O-ACYLTRANSFERASE IN AORTIC MICROSOMES FROM ATHEROSCLEROTIC RABBITS [J].