RFX1, A TRANSACTIVATOR OF HEPATITIS-B VIRUS ENHANCER-I, BELONGS TO A NOVEL FAMILY OF HOMODIMERIC AND HETERODIMERIC DNA-BINDING PROTEINS

被引:132
作者
REITH, W [1 ]
UCLA, C [1 ]
BARRAS, E [1 ]
GAUD, A [1 ]
DURAND, B [1 ]
HERREROSANCHEZ, C [1 ]
KOBR, M [1 ]
MACH, B [1 ]
机构
[1] UNIV GENEVA,SCH MED,CTR MED,DEPT GENET & MICROBIOL,JEANTET LAB MOLEC GENET,CH-1211 GENEVA 4,SWITZERLAND
关键词
D O I
10.1128/MCB.14.2.1230
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
RFX1 is a transactivator of human hepatitis B virus enhancer I. We show here that RFX1 belongs to a previously unidentified family of DNA-binding proteins of which we have cloned three members, RFX1, RFX2, and RFX3, from humans and mice. Members of the RFX family constitute the nuclear complexes that have been referred to previously as enhancer factor C, EP, methylation-dependent DNA-binding protein, or rpL30 alpha. RFX proteins share five strongly conserved regions which include the two domains required for DNA binding and dimerization. They have very similar DNA-binding specificities and heterodimerize both in vitro and in vivo. mRNA levels for all three genes, particularly RFX2, are elevated in testis. In other cell lines and tissues, RFX mRNA levels are variable, particularly for RFXZ and RFX3. RFX proteins share several novel features, including new DNA-binding and dimerization motifs and a peculiar dependence on methylated CpG dinucleotides at certain
引用
收藏
页码:1230 / 1244
页数:15
相关论文
共 53 条
[1]   Structure of the leucine zipper [J].
Alber, Tom .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1992, 2 (02) :205-210
[2]   INTERACTIONS OF COILED COILS IN TRANSCRIPTION FACTORS - WHERE IS THE SPECIFICITY [J].
BAXEVANIS, AD ;
VINSON, CR .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1993, 3 (02) :278-285
[3]   REGULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II GENES - X, Y AND OTHER LETTERS OF THE ALPHABET [J].
BENOIST, C ;
MATHIS, D .
ANNUAL REVIEW OF IMMUNOLOGY, 1990, 8 :681-715
[4]   DNA METHYLATION INHIBITS TRANSCRIPTION INDIRECTLY VIA A METHYL-CPG BINDING-PROTEIN [J].
BOYES, J ;
BIRD, A .
CELL, 1991, 64 (06) :1123-1134
[5]   REPRESSION OF GENES BY DNA METHYLATION DEPENDS ON CPG DENSITY AND PROMOTER STRENGTH - EVIDENCE FOR INVOLVEMENT OF A METHYL-CPG BINDING-PROTEIN [J].
BOYES, J ;
BIRD, A .
EMBO JOURNAL, 1992, 11 (01) :327-333
[6]   ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].
CHIRGWIN, JM ;
PRZYBYLA, AE ;
MACDONALD, RJ ;
RUTTER, WJ .
BIOCHEMISTRY, 1979, 18 (24) :5294-5299
[7]   FUNCTIONAL-ORGANIZATION OF THE HEPATITIS-B VIRUS ENHANCER [J].
DIKSTEIN, R ;
FAKTOR, O ;
BENLEVY, R ;
SHAUL, Y .
MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (07) :3683-3689
[8]   CHARACTERIZATION OF ESTROGEN-RECEPTOR VARIANT MESSENGER-RNAS FROM HUMAN BREAST CANCERS [J].
DOTZLAW, H ;
ALKHALAF, M ;
MURPHY, LC .
MOLECULAR ENDOCRINOLOGY, 1992, 6 (05) :773-785
[9]   COMPILATION OF VERTEBRATE-ENCODED TRANSCRIPTION FACTORS [J].
FAISST, S ;
MEYER, S .
NUCLEIC ACIDS RESEARCH, 1992, 20 (01) :3-26
[10]   METHYLATION-DEPENDENT AND METHYLATION-INDEPENDENT DNA-BINDING OF NUCLEAR FACTOR EF-C [J].
GARCIA, AD ;
OSTAPCHUK, P ;
HEARING, P .
VIROLOGY, 1991, 182 (02) :857-860