THE NA,K-ATPASE HYPOTHESIS FOR BIPOLAR ILLNESS

被引:156
作者
ELMALLAKH, RS [1 ]
WYATT, RJ [1 ]
机构
[1] NIMH, NEUROPSYCHIAT RES HOSP, NEUROPSYCHIAT BRANCH, WASHINGTON, DC 20032 USA
关键词
BIPOLAR ILLNESS; CALCIUM; LITHIUM; MANIC-DEPRESSION; NA; K-ATPASE; POTASSIUM; SODIUM;
D O I
10.1016/0006-3223(94)00201-D
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A cellular model for bipolar illness is presented. It is propounded that alterations in the activity of the membrane sodium- and potassium-activated adenosine triphosphatase pump (Na,K-ATPase) may be responsible for alterations in neuronal excitability and activity. Specifically, a reduction in Na,K-ATPase activity can lead to both mania and depression by increasing membrane excitability and decreasing neurotransmitter release, respectively. Supporting evidence is reviewed, and clinical and research implications are discussed.
引用
收藏
页码:235 / 244
页数:10
相关论文
共 134 条
[1]   ACTIVITY OF ERYTHROCYTE NA,K-ATPASE IN MANIC PATIENTS [J].
AKAGAWA, K ;
WATANABE, M ;
TSUKADA, Y .
JOURNAL OF NEUROCHEMISTRY, 1980, 35 (01) :258-260
[2]   SODIUM-POTASSIUM, MAGNESIUM, AND CALCIUM ATPASE ACTIVITIES IN ERYTHROCYTE-MEMBRANES FROM MANIC-DEPRESSIVE PATIENTS RESPONDING TO LITHIUM [J].
ALEXANDER, DR ;
DEEB, M ;
BITAR, F ;
ANTUN, F .
BIOLOGICAL PSYCHIATRY, 1986, 21 (11) :997-1007
[3]  
ALMY GL, 1973, ARCH GEN PSYCHIAT, V29, P232
[4]   ON PERMEABILITY OF MAMMALIAN NON-MYELINATED FIBRES TO SODIUM AND TO LITHIUM IONS [J].
ARMETT, CJ ;
RITCHIE, JM .
JOURNAL OF PHYSIOLOGY-LONDON, 1963, 165 (01) :130-&
[5]   OXYGEN AND GLUCOSE CONSUMPTION RELATED TO NA+-K+ TRANSPORT IN CANINE BRAIN [J].
ASTRUP, J ;
SORENSEN, PM ;
SORENSEN, HR .
STROKE, 1981, 12 (06) :726-730
[6]   BENNETT,AE AWARD PAPER MUSCARINIC RECEPTOR SUBCLASSIFICATION AND G-PROTEINS - SIGNIFICANCE FOR LITHIUM ACTION IN AFFECTIVE-DISORDERS AND FOR THE TREATMENT OF THE EXTRAPYRAMIDAL SIDE-EFFECTS OF NEUROLEPTICS [J].
AVISSAR, S ;
SCHREIBER, G .
BIOLOGICAL PSYCHIATRY, 1989, 26 (02) :113-130
[7]   LITHIUM INHIBITS ADRENERGIC AND CHOLINERGIC INCREASES IN GTP BINDING IN RAT CORTEX [J].
AVISSAR, S ;
SCHREIBER, G ;
DANON, A ;
BELMAKER, RH .
NATURE, 1988, 331 (6155) :440-442
[8]  
BAER L, 1970, ARCH GEN PSYCHIAT, V22, P40
[9]  
Baker P F, 1972, Prog Biophys Mol Biol, V24, P177, DOI 10.1016/0079-6107(72)90007-7
[10]   INFLUENCE OF CALCIUM ON SODIUM EFFLUX IN SQUID AXONS [J].
BAKER, PF ;
BLAUSTEIN, MP ;
HODGKIN, AL ;
STEINHARDT, RA .
JOURNAL OF PHYSIOLOGY-LONDON, 1969, 200 (02) :431-+