THE NA,K-ATPASE HYPOTHESIS FOR BIPOLAR ILLNESS

被引：156

作者：

ELMALLAKH, RS ^{[1
]}

WYATT, RJ ^{[1
]}

机构：

[1] NIMH, NEUROPSYCHIAT RES HOSP, NEUROPSYCHIAT BRANCH, WASHINGTON, DC 20032 USA

来源：

BIOLOGICAL PSYCHIATRY | 1995年 / 37卷 / 04期

关键词：

BIPOLAR ILLNESS; CALCIUM; LITHIUM; MANIC-DEPRESSION; NA; K-ATPASE; POTASSIUM; SODIUM;

D O I：

10.1016/0006-3223(94)00201-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A cellular model for bipolar illness is presented. It is propounded that alterations in the activity of the membrane sodium- and potassium-activated adenosine triphosphatase pump (Na,K-ATPase) may be responsible for alterations in neuronal excitability and activity. Specifically, a reduction in Na,K-ATPase activity can lead to both mania and depression by increasing membrane excitability and decreasing neurotransmitter release, respectively. Supporting evidence is reviewed, and clinical and research implications are discussed.

引用

页码：235 / 244

页数：10

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