THE NA,K-ATPASE HYPOTHESIS FOR BIPOLAR ILLNESS

被引:156
作者
ELMALLAKH, RS [1 ]
WYATT, RJ [1 ]
机构
[1] NIMH, NEUROPSYCHIAT RES HOSP, NEUROPSYCHIAT BRANCH, WASHINGTON, DC 20032 USA
关键词
BIPOLAR ILLNESS; CALCIUM; LITHIUM; MANIC-DEPRESSION; NA; K-ATPASE; POTASSIUM; SODIUM;
D O I
10.1016/0006-3223(94)00201-D
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A cellular model for bipolar illness is presented. It is propounded that alterations in the activity of the membrane sodium- and potassium-activated adenosine triphosphatase pump (Na,K-ATPase) may be responsible for alterations in neuronal excitability and activity. Specifically, a reduction in Na,K-ATPase activity can lead to both mania and depression by increasing membrane excitability and decreasing neurotransmitter release, respectively. Supporting evidence is reviewed, and clinical and research implications are discussed.
引用
收藏
页码:235 / 244
页数:10
相关论文
共 134 条
[21]   FRONTAL-CORTEX AND BASAL GANGLIA METABOLIC RATES ASSESSED BY POSITRON EMISSION TOMOGRAPHY WITH [F-18] 2-DEOXYGLUCOSE IN AFFECTIVE-ILLNESS [J].
BUCHSBAUM, MS ;
WU, J ;
DELISI, LE ;
HOLCOMB, H ;
KESSLER, R ;
JOHNSON, J ;
KING, AC ;
HAZLETT, E ;
LANGSTON, K ;
POST, RM .
JOURNAL OF AFFECTIVE DISORDERS, 1986, 10 (02) :137-152
[22]  
CARAFOLI E, 1987, CELL CALCIUM CONTROL, P21
[23]  
CARILLI CT, 1985, J BIOL CHEM, V260, P1027
[24]  
CARMAN JS, 1979, BIOL PSYCHIAT, V14, P295
[26]  
CARROLL BJ, 1972, DEPRESSIVE ILLNESS S, P249
[27]  
CASPER RC, 1976, LANCET, V2, P418
[28]  
CHOI SJ, 1977, BIOL PSYCHIAT, V12, P75
[29]   POSSIBLE ROLE OF ENDOGENOUS OUABAIN-LIKE COMPOUNDS IN THE PATHOPHYSIOLOGY OF BIPOLAR ILLNESS [J].
CHRISTO, PJ ;
ELMALLAKH, RS .
MEDICAL HYPOTHESES, 1993, 41 (04) :378-383
[30]   MINERAL METABOLISM IN MELANCHOLIA [J].
COPPEN, A ;
SHAW, DM .
BRITISH MEDICAL JOURNAL, 1963, (537) :1439-&