MULTIPURPOSE RECEPTOR LIGANDS - BETA-CARBOLINE CHOLECYSTOKININ ANTAGONISTS

被引：5

作者：

EVANS, BE

RITTLE, KE

CHANG, RSL

LOTTI, VJ

FREEDMAN, SB

FREIDINGER, RM

机构：

[1] MSD,NEUROSCI RES CTR,RES LABS,HARLOW,ESSEX,ENGLAND

[2] MERCK & CO INC,DEPT NEW LEAD PHARMACOL,RES LAB,W POINT,PA 19486

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)80682-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New amides and ureas of 3-amino-beta-carboline are described which are selective ligands for CCK-A receptors. These compounds are developed by adaptation of benzodiazepine receptor-selective beta-carboline-3-carboxylic esters. New CCK-A antagonists with 10(-8)M receptor affinities are reported.

引用

收藏

页码：867 / 870

页数：4

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