AGE-DEPENDENT SOMATIC EXCISION OF TRANSPOSABLE ELEMENT TC1 IN CAENORHABDITIS-ELEGANS

被引：16

作者：

EGILMEZ, NK

REIS, RJS

机构：

[1] UNIV ARKANSAS MED SCI HOSP,JOHN L MCCLELLAN VET MED CTR,DEPT MED,LITTLE ROCK,AR 72205

[2] UNIV ARKANSAS MED SCI HOSP,JOHN L MCCLELLAN VET MED CTR,DEPT BIOCHEM & MOLEC BIOL,LITTLE ROCK,AR 72205

来源：

MUTATION RESEARCH | 1994年 / 316卷 / 01期

关键词：

CAENORHABDITIS ELEGANS; TRANSPOSABLE ELEMENT; TRANSPOSON; TC1; SOMATIC EXCISION; AGING;

D O I：

10.1016/0921-8734(94)90004-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Tc1 element of the free-living nematode Caenorhabditis elegans is a well characterized transposon that is present in 30-500 copies per haploid genome, depending on the strain. Excision of Tc1 elements, which occurs readily in somatic tissues during larval development, has not previously been examined during aging of adult worms. We have identified a recently inserted Tc1 element in the KR1787 mutator strain of C. elegans and have found that Tc1 somatic excision at that site increases by more than 14-fold during the organism's lifespan.

引用

页码：17 / 24

页数：8

共 31 条

[1]

ABAD P, 1992, WORM BREEDERS GAZETT, V12, P90

[2]

ABAD P, 1992, WORM BREEDERS GAZETT, V12, P88

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