miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1

被引：107

作者：

Ke, Yang ^{[1
]}

Zhao, Weiyong ^{[2
]}

Xiong, Jie ^{[1
]}

Cao, Rubo ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Canc Ctr, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China

[2] Nanjing Med Univ, Affiliated Hosp 2, Dept Oncol, Nanjing 210011, Jiangsu, Peoples R China

来源：

BIOCHEMISTRY RESEARCH INTERNATIONAL | 2013年 / 2013卷

关键词：

D O I：

10.1155/2013/506731

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

MicroRNAs (miRNAs) have been implied to play crucial roles for epithelial-to-mesenchymal transition (EMT) of non-smallcell lung cancer cells (NSCLC cells). Here we found that the expression of miR-149, downregulated in lung cancer, was inversely correlated with invasive capability and the EMT phenotype of NSCLC cells. miR-149 inhibited EMT in NSCLC cells. Furthermore, we demonstrated that miR-149 directly targeted Forkhead box M1 (FOXM1), and FOXM1 was involved in the EMT induced by TGF-beta 1. 1 in A549 cells. Overexpression of FOXM1 restored EMT process inhibited by miR-149. Our work suggested that miR-149 might be an EMT suppressor in NSCLC cells.

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