ASYMMETRIC NUCLEOPHILIC-ADDITION OF CHIRAL BETA-ENAMINO ESTERS TO ACRYLONITRILE

被引：11

作者：

GUINGANT, A ^{[1
]}

HAMMAMI, H ^{[1
]}

机构：

[1] BIO CIS,CTR ETUDES PHARMACEUT,CNRS,ERS 0045,F-92296 CHATENAY MALABRY,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 01期

关键词：

CHIRAL BETA-ENAMINO ESTERS; OPTICALLY ACTIVE ALPHA; ALPHA-DISUBSTITUTED BETA-KETO ESTERS; ASYMMETRIC MICHAEL ADDITION; LEWIS ACIDS; HIGH PRESSURE;

D O I：

10.1016/S0957-4166(00)86008-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Beta - enamino esters derived from beta - keto ester.5 and (S)-1- phenylethylamine, react with acrylonitrile in the presence of a Lewis acid or under high pressure activation to give, after hydrolytic work up, alpha,alpha - disubstituted beta - keto esters 4 (EWG=CN) in enantiomeric excesses close to 90%.

引用

页码：25 / 26

页数：2

共 7 条

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[7] ASYMMETRIC MICHAEL ADDITION OF CHIRAL ENAMINOESTERS TO PHENYL VINYL SULFONE AND 1,1-BIS(PHENYLSULFONYL)ETHYLENE [J].

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