Genetic risk in micromanipulative assisted reproduction

被引：61

作者：

Meschede, D

DeGeyter, C

Nieschlag, E

Horst, J

机构：

[1] UNIV MUNSTER,WOMENS HOSP,D-48149 MUNSTER,GERMANY

[2] UNIV MUNSTER,INST REPROD MED,D-48149 MUNSTER,GERMANY

来源：

HUMAN REPRODUCTION | 1995年 / 10卷 / 11期

关键词：

assisted reproduction; genetic disease; intracytoplasmic sperm injection; risk evaluation; teratogenesis;

D O I：

10.1093/oxfordjournals.humrep.a135812

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The empirical data on pregnancy outcome after intracytoplasmic sperm injection (ICSI) are encouraging, but still insufficient to rule out definitely adverse genetic or teratological effects, We analyse potential adverse effects of ICSI by applying general principles of genetic and teratological risk assessment. The role of gamete micromanipulation as a possible teratogen is discussed. We consider whether ICSI patients are at increased risk for carrying and propagating genetic lesions of different kinds, The possible interference of ICSI with genomic imprinting and pre-zygotic sperm selection is reviewed and we discuss the potentially protective role of DNA repair in oocytes. Considering the available empirical data and the conclusions from our theoretical analysis it appears that neither lassitude nor over-concern about adverse effects of ICSI are justified.

引用

页码：2880 / 2886

页数：7

共 72 条

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