METABOLITES OF (+)-DEHYDROABIETIC ACID IN RABBITS

被引：16

作者：

MATSUMOTO, T

HAYASHI, N

ISHIDA, T

ASAKAWA, Y

机构：

[1] TOKUSHIMA BUNRI UNIV,FAC PHARMACEUT SCI,YAMASHIRO CHO,TOKUSHIMA 770,JAPAN

[2] HIROSHIMA UNIV,FAC SCI,DEPT CHEM,HIGASHISENDA MACHI,NAKA KU,HIROSHIMA 770,JAPAN

[3] HIROSHIMA INST TECHNOL,SAEKI KU,HIROSHIMA 73151,JAPAN

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1990年 / 79卷 / 06期

关键词：

D O I：

10.1002/jps.2600790618

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The seven metabolites of (+)‐dehydroabietic acid (DHA) were newly isolated from rabbit urine by liquid chromatography. On the basis of chemical and spectral data their structures were established to be (15S)‐8, 11, 13‐abietatrien‐16, 18‐dioic acid, 2α‐hydroxy‐8, 11, 13, 15‐abietatetraen‐18‐oic acid, (15R)‐15, 16‐dihydroxy‐8, 11, 13‐abietatrien‐18‐oic acid, 2β, 15‐dihydroxy‐8, 11, 13‐abietatrien‐18‐oic acid, (15S)‐20, 16‐dihydroxy‐8, 11, 13‐abietatrien‐18‐oic acid, 2α, 15‐dihydroxy‐8, 11, 13‐abietatrien‐18‐oic acid, and (15S)‐2α, 16‐dihydroxy‐8, 11, 13‐abietatrien‐18‐oic acid. The possible hydroxylation routes of DHA in rabbits and the difference between the metabolism of DHA in microorganisms and that in rabbits are discussed. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：540 / 547

页数：8

共 30 条

[21] THE SYNTHESIS OF METHYL (15S)-16-HYDROXYDEHYDROABIETATE AND ITS (15R)-EPIMER [J].