LIGAND-INDEPENDENT REPRESSION BY THE THYROID-HORMONE RECEPTOR-MEDIATED BY A NUCLEAR RECEPTOR CO-REPRESSOR

被引：1666

作者：

HORLEIN, AJ

NAAR, AM

HEINZEL, T

TORCHIA, J

GLOSS, B

KUROKAWA, R

RYAN, A

KAMEL, Y

SODERSTROM, M

GLASS, CK

ROSENFELD, MG

机构：

[1] UNIV CALIF SAN DIEGO, DEPT MED, GRAD PROGRAM MOLEC PATHOL, LA JOLLA, CA 92093 USA

[2] UNIV CALIF SAN DIEGO, SCH MED, LA JOLLA, CA 92093 USA

来源：

NATURE | 1995年 / 377卷 / 6548期

关键词：

D O I：

10.1038/377397a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.

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页码：397 / 404

页数：8

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