DIORGANOTIN DIFLUOROBENZOATES - SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND IN-VITRO ANTITUMOR-ACTIVITY - X-RAY STRUCTURE DETERMINATION OF BIS[DI-N-BUTYL(2,6-DIFLUOROBENZOATO)TIN] OXIDE

The synthesis and spectroscopic characterization of diorganotin(IV) bis(difluorobenzoates) [F2C6H3COO]2SnR2 [type a] and bis[diorgano(difluorobenzoato)tin(IV)] oxides {[(F2C6H3COO)R2Sn]2O}2 [type b] are described. An X-ray structure study has revealed compound 3b, {[(2,6-F2C6H3COO)(n-C4H9)2Sn]2O}2, to be dimeric and built around a planar Sn2O2 ring. The crystals are triclinic P1BAR with the cell dimensions a=11.935(13), b=12.3675(14), c=12.974 angstrom, alpha=92.89(8), beta=84.32(7), gamma=67.49(9)-degrees; Z=1, with the dimer being centro-symmetric. Selected compounds have been tested in vitro against two human tumour cell lines, MCF-7 (a mammary tumour) and WiDr (a colon carcinoma), and exhibit promising cytotoxicities.