6-ENDO-TRIG RADICAL CYCLIZATIONS - SYNTHETIC APPROACHES TO THE A-B-RING OF (+/-)-FORSKOLIN

被引：11

作者：

ANIES, C ^{[1
]}

BILLOT, L ^{[1
]}

LALLEMAND, JY ^{[1
]}

PANCRAZI, A ^{[1
]}

机构：

[1] ECOLE POLYTECH,DCSO,CNRS,SYNTH ORGAN LAB,F-91128 PALAISEAU,FRANCE

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 40期

关键词：

D O I：

10.1016/0040-4039(95)01498-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In a synthetic approach to forskolin 1, a 6-endo-trig radical cyclisation was performed on propargylic derivative 12 to furnish in 60% yield compound 17 which contains the A-B ring system of forskolin. In the same way yn-one 14 submitted to Bu(3)SnH gave the expected cyclised product 19 in 55% yield A particular 5-exo-dig cyclisation took place, leading to compound 18 in 10% yield, when silylated propargylic alcohol 13 was treated under the sane conditions.

引用

页码：7247 / 7250

页数：4

共 18 条

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