CROSS-REACTIVE ANTIGENS BETWEEN LIFE-CYCLE STAGES OF PLASMODIUM-FALCIPARUM

被引：14

作者：

MOELANS, IIMD

SCHOENMAKERS, JGG

机构：

[1] Department of Molecular Biology, University of Nijmegen

来源：

PARASITOLOGY TODAY | 1992年 / 8卷 / 04期

关键词：

D O I：

10.1016/0169-4758(92)90278-A

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The high mortality and morbidity induced by falciparum malaria has motivated research to find an efficient antimalarial vaccine. The parasite has a complex life cycle, both in the mosquito and human hosts, and presents a number of potential targets for vaccine-induced immune attack. Here, Inge Moelans and John Schoenmakers discuss how the search for protective antigens has been complicated by the discovery of multiple crossreactivities between different parasite proteins.

引用

收藏

页码：118 / 123

页数：6

相关论文

共 40 条

[1] PLASMODIUM SEXUAL STAGE ANTIGENS [J].

ALANO, P .

PARASITOLOGY TODAY, 1991, 7 (08) :199-203

[2] MULTIPLE CROSS-REACTIVITIES AMONGST ANTIGENS OF PLASMODIUM-FALCIPARUM IMPAIR THE DEVELOPMENT OF PROTECTIVE IMMUNITY AGAINST MALARIA [J].

ANDERS, RF .

PARASITE IMMUNOLOGY, 1986, 8 (06) :529-539

[3] CROSS-REACTIVE ASPARAGINE-RICH DETERMINANTS SHARED BETWEEN SEVERAL BLOOD-STAGE ANTIGENS OF PLASMODIUM-FALCIPARUM AND THE CIRCUMSPOROZOITE PROTEIN [J].

ARDESHIR, F ;

HOWARD, RF ;

VIRIYAKOSOL, S ;

ARAD, O ;

REESE, RT .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1990, 40 (01) :113-128

[4] PROTEOLYTIC PROCESSING OF THE PLASMODIUM-FALCIPARUM MEROZOITE SURFACE PROTEIN-1 PRODUCES A MEMBRANE-BOUND FRAGMENT CONTAINING 2 EPIDERMAL GROWTH FACTOR-LIKE DOMAINS [J].

BLACKMAN, MJ ;

LING, IT ;

NICHOLLS, SC ;

HOLDER, AA .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1991, 49 (01) :29-34

[5] PRIMARY STRUCTURE AND LOCALIZATION OF A CONSERVED IMMUNOGENIC PLASMODIUM-FALCIPARUM GLUTAMATE RICH PROTEIN (GLURP) EXPRESSED IN BOTH THE PREERYTHROCYTIC AND ERYTHROCYTIC STAGES OF THE VERTEBRATE LIFE-CYCLE [J].

BORRE, MB ;

DZIEGIEL, M ;

HOGH, B ;

PETERSEN, E ;

RIENECK, K ;

RILEY, E ;

MEIS, JF ;

AIKAWA, M ;

NAKAMURA, K ;

HARADA, M ;

WIND, A ;

JAKOBSEN, PH ;

COWLAND, J ;

JEPSEN, S ;

AXELSEN, NH ;

VUUST, J .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1991, 49 (01) :119-132

[6] DIFFERENTIAL ANTIBODY-RESPONSES TO PLASMODIUM-FALCIPARUM AND PLASMODIUM-VIVAX CIRCUMSPOROZOITE PROTEINS IN A HUMAN-POPULATION [J].

BURKOT, TR ;

GRAVES, PM ;

WIRTZ, RA ;

BRABIN, BJ ;

BATTISTUTTA, D ;

CATTANI, JA ;

MAIZELS, RM ;

ALPERS, MP .

JOURNAL OF CLINICAL MICROBIOLOGY, 1989, 27 (06) :1346-1351

[7] A PLASMODIUM-FALCIPARUM MALARIA VACCINE CANDIDATE WHICH CONTAINS EPITOPES FROM THE CIRCUMSPOROZOITE PROTEIN AND A BLOOD STAGE ANTIGEN, 5.1 [J].

CASPERS, P ;

ETLINGER, H ;

MATILE, H ;

PINK, JR ;

STUBER, D ;

TAKACS, B .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1991, 47 (02) :143-150

[8] PERSISTENCE OF CELLULAR AND HUMORAL RESPONSE TO SYNTHETIC PEPTIDES FROM DEFINED PLASMODIUM-FALCIPARUM ANTIGENS [J].

CHOUGNET, C ;

DELORON, P ;

SAVEL, J .

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1991, 85 (03) :357-363

[9] A BLOOD STAGE ANTIGEN OF PLASMODIUM-FALCIPARUM SHARES DETERMINANTS WITH THE SPOROZOITE COAT PROTEIN [J].

COPPEL, RL ;

FAVALORO, JM ;

CREWTHER, PE ;

BURKOT, TR ;

BIANCO, AE ;

STAHL, HD ;

KEMP, DJ ;

ANDERS, RF ;

BROWN, GV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (15) :5121-5125

[10] MALARIA VACCINES - PROGRESS AND PROBLEMS [J].

COX, FEG .

TRENDS IN BIOTECHNOLOGY, 1991, 9 (11) :389-393

← 1 2 3 4 →