ASSOCIATION OF EPSTEIN-BARR-VIRUS GENOME WITH MIXED CELLULARITY AND CELLULAR-PHASE NODULAR SCLEROSIS HODGKINS-DISEASE SUBTYPES

被引：20

作者：

BOIOCCHI, M

DE RE, V

DOLCETTI, R

CARBONE, A

SCARPA, A

MENESTRINA, F

机构：

[1] CTR RIFERIMENTO ONCOL, DEPT PATHOL, I-33081 AVIANO, ITALY

[2] UNIV VERONA, DEPT PATHOL, I-37100 VERONA, ITALY

来源：

ANNALS OF ONCOLOGY | 1992年 / 3卷 / 04期

关键词：

EPSTEIN-BARR VIRUS; HODGKINS DISEASE; POLYMERASE CHAIN REACTION;

D O I：

10.1093/oxfordjournals.annonc.a058187

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Association of Epstein-Barr virus (EBV) genome with Hodgkin's disease (HD) histological subtypes was investigated using the polymerase chain reaction (PCR). A highly significant association of EBV genome with the mixed cellularity (MC) subtype (10 positive out of 15 cases; 66%) was observed, suggesting a possible etiopathogenetic role of EBV in the induction of this subset. By contrast, a markedly lower frequency of association with EBV genome was found in nodular sclerosis (NS) (12 positive out of 46 cases; 26%) and in nodular lymphocytic predominance (NLP) (0 positive out of 5 cases) HD subtypes. In addition, in the NS series, the presence of EBV genome was mainly restricted to the 'cellular phase' NS subset. This finding strengthens the possibility, suggested by clinico-pathological features and survival rates, that 'cellular phase NS' is a disease more akin to MC than to typical NS HD.

引用

页码：307 / 310

页数：4

共 30 条

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