A NOVEL ENANTIOSELECTIVE SYNTHESIS OF HMG CO-A REDUCTASE INHIBITOR NK-104 AND A RELATED COMPOUND

被引：22

作者：

MINAMI, T ^{[1
]}

HIYAMA, T ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR,4-4-1 NISHIOHNUMA,SAGAMIHARA,KANAGAWA 229,JAPAN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(00)60814-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically active methyl 6-oxo-3.5-syn-isopropylidenedioxyhexanoate (5) was prepared by enantioselective syn-reduction of beta,delta-diketo ester 2, followed by hydrolysis, protection of the diol moiety and ozonolysis, and was converted into a highly potent HMG Co-A reductase inhibitor NK-104 and an analogue.

引用

页码：7525 / 7526

页数：2

共 8 条

[1] BAADER E, 1990, TETRAHEDRON LETT, V31, P2545
[2] COMPACTIN (ML-236B) AND RELATED-COMPOUNDS AS POTENTIAL CHOLESTEROL-LOWERING AGENTS THAT INHIBIT HMG-COA REDUCTASE
ENDO, A
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (04) : 401 - 405
[3] A HIGHLY STEREOSELECTIVE ROUTE TO THE 4 STEREOISOMERS OF A 6-CARBON SYNTHON
PRASAD, K
CHEN, KM
REPIC, O
HARDTMANN, GE
[J]. TETRAHEDRON-ASYMMETRY, 1990, 1 (05) : 307 - 310
[4] ENANTIOSELECTIVE SYNTHESIS OF BETA-HYDROXY DELTA-LACTONES - A NEW APPROACH TO THE SYNTHETIC CONGENERS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE INHIBITORS
REDDY, GB
MINAMI, T
HANAMOTO, T
HIYAMA, T
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (20) : 5752 - 5754
[5] RELATIONSHIP BETWEEN TISSUE SELECTIVITY AND LIPOPHILICITY FOR INHIBITORS OF HMG-COA REDUCTASE
ROTH, BD
BOCAN, TMA
BLANKLEY, CJ
CHUCHOLOWSKI, AW
CREGER, PL
CRESWELL, MW
FERGUSON, E
NEWTON, RS
OBRIEN, P
PICARD, JA
ROARK, WH
SEKERKE, CS
SLISKOVIC, DR
WILSON, MW
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) : 463 - 466
[6] 3-HYDROXY-3-METHYLGLUTARYL-COENZYME-A REDUCTASE INHIBITORS .1. STRUCTURAL MODIFICATION OF 5-SUBSTITUTED 3,5-DIHYDROXYPENTANOIC ACIDS AND THEIR LACTONE DERIVATIVES
STOKKER, GE
HOFFMAN, WF
ALBERTS, AW
CRAGOE, EJ
DEANA, AA
GILFILLAN, JL
HUFF, JW
NOVELLO, FC
PRUGH, JD
SMITH, RL
WILLARD, AK
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (03) : 347 - 358
[7] STEREOSELECTIVE SYNTHESIS OF HR 780 A NEW HIGHLY POTENT HMG-COA REDUCTASE INHIBITOR
WESS, G
KESSELER, K
BAADER, E
BARTMANN, W
BECK, G
BERGMANN, A
JENDRALLA, H
BOCK, K
HOLZSTEIN, G
KLEINE, H
SCHNIERER, M
[J]. TETRAHEDRON LETTERS, 1990, 31 (18) : 2545 - 2548
[8] 1992, 11 INT S DRUGS AFF L

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