DIETARY RESTRICTION

被引：82

作者：

MASORO, EJ

机构：

[1] Aging Research and Education Center, University of Texas Health Science Center at San Antonio

来源：

EXPERIMENTAL GERONTOLOGY | 1995年 / 30卷 / 3-4期

关键词：

GOMPERTZ ANALYSIS; BIOLOGICAL AGE; DIETARY RESTRICTION; ENERGY INTAKE; METABOLIC RATE; CARBOHYDRATE METABOLISM; GLYCEMIA; INSULINEMIA; GLUCOCORTICOIDS; HEAT SHOCK PROTEINS;

D O I：

10.1016/0531-5565(94)00028-2

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Dietary restriction (DR) slows the rate of actuarial aging of rats and mice and in addition retards and/or delays many phenotypic characteristics of aging such as the age-associated deterioration of physiological systems and the occurrence and progression of age-associated disease. These antiaging actions result from a reduction of energy intake by the animal but are not due to a decrease in metabolic rate per unit of lean body mass. However, there is evidence that altered characteristics of fuel use (but not the intensity of fuel use) may underlie the antiaging action of DR. There is also evidence that DR has a general protective action in regard to damage caused by acute stressors; possibly a similar protective action in regard to damage caused by prolonged, low intensity aging processes plays a major role in the antiaging action of DR.

引用

页码：291 / 298

页数：8

共 27 条

[11] EXPRESSION OF HEAT-SHOCK PROTEIN 70 IS ALTERED BY AGE AND DIET AT THE LEVEL OF TRANSCRIPTION [J].