DIETARY RESTRICTION

被引:82
作者
MASORO, EJ
机构
[1] Aging Research and Education Center, University of Texas Health Science Center at San Antonio
关键词
GOMPERTZ ANALYSIS; BIOLOGICAL AGE; DIETARY RESTRICTION; ENERGY INTAKE; METABOLIC RATE; CARBOHYDRATE METABOLISM; GLYCEMIA; INSULINEMIA; GLUCOCORTICOIDS; HEAT SHOCK PROTEINS;
D O I
10.1016/0531-5565(94)00028-2
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Dietary restriction (DR) slows the rate of actuarial aging of rats and mice and in addition retards and/or delays many phenotypic characteristics of aging such as the age-associated deterioration of physiological systems and the occurrence and progression of age-associated disease. These antiaging actions result from a reduction of energy intake by the animal but are not due to a decrease in metabolic rate per unit of lean body mass. However, there is evidence that altered characteristics of fuel use (but not the intensity of fuel use) may underlie the antiaging action of DR. There is also evidence that DR has a general protective action in regard to damage caused by acute stressors; possibly a similar protective action in regard to damage caused by prolonged, low intensity aging processes plays a major role in the antiaging action of DR.
引用
收藏
页码:291 / 298
页数:8
相关论文
共 27 条
[21]   ENERGY-METABOLISM AND AGING - A LIFELONG STUDY OF FISCHER-344 RATS [J].
MCCARTER, RJ ;
PALMER, J .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (03) :E448-E452
[22]   The effect of retarded growth upon the length of life span and upon the ultimate body size [J].
McCay, CM ;
Crowell, MF ;
Maynard, LA .
JOURNAL OF NUTRITION, 1935, 10 (01) :63-79
[23]   PHYSIOLOGICAL FUNCTIONS OF GLUCOCORTICOIDS IN STRESS AND THEIR RELATION TO PHARMACOLOGICAL ACTIONS [J].
MUNCK, A ;
GUYRE, PM ;
HOLBROOK, NJ .
ENDOCRINE REVIEWS, 1984, 5 (01) :25-44
[24]  
REAVEN GM, 1989, CLIN GUIDE NONINSULI
[25]   ASSESSMENT OF THE ROLE OF THE GLUCOCORTICOID SYSTEM IN AGING PROCESSES AND IN THE ACTION OF FOOD RESTRICTION [J].
SABATINO, F ;
MASORO, EJ ;
MCMAHAN, CA ;
KUHN, RW .
JOURNALS OF GERONTOLOGY, 1991, 46 (05) :B171-B179
[26]   LIFE-SPAN STUDY OF SPF FISCHER-344 MALE-RATS FED AD-LIBITUM OR RESTRICTED DIETS - LONGEVITY, GROWTH, LEAN BODY-MASS AND DISEASE [J].
YU, BP ;
MASORO, EJ ;
MURATA, I ;
BERTRAND, HA ;
LYND, FT .
JOURNALS OF GERONTOLOGY, 1982, 37 (02) :130-141
[27]   NUTRITIONAL INFLUENCES ON AGING OF FISCHER-344 RATS .1. PHYSICAL, METABOLIC, AND LONGEVITY CHARACTERISTICS [J].
YU, BP ;
MASORO, EJ ;
MCMAHAN, CA .
JOURNALS OF GERONTOLOGY, 1985, 40 (06) :657-670