SYNTHESIS OF 1233A ANALOGS AND THEIR INHIBITORY ACTIVITY AGAINST HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE

被引：21

作者：

SUNAZUKA, T

TSUZUKI, K

KUMAGAI, H

TOMODA, H

TANAKA, H

NAGASHIMA, H

HASHIZUME, H

OMURA, S

机构：

[1] KITASATO INST,BIOL FUNCT RES CTR,MINATO KU,TOKYO 108,JAPAN

[2] DAHCHI PHARMACEUT CO LTD,EDOGAWA KU,TOKYO 134,JAPAN

[3] FUJI CHEM IND CO LTD,TAKAOKA,TOYAMA 933,JAPAN

[4] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 07期

关键词：

D O I：

10.7164/antibiotics.45.1139

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Simple and efficient syntheses of 1233A analogs were developed and the inhibitory activity of the analogs against hydroxymethylglutaryl coenzyme A (HMG-CoA) synthase was determined. Study of the structure-activity relationships revealed that not only the geometry in beta-lactone moiety but also the length of the carbon side chain is important for inhibitory activity against HMG-CoA synthase.

引用

页码：1139 / 1147

页数：9

共 11 条

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