A TBP-TAF COMPLEX REQUIRED FOR TRANSCRIPTION OF HUMAN SNRNA GENES BY RNA-POLYMERASE-II AND RNA-POLYMERASE-III

被引：128

作者：

HENRY, RW ^{[1
]}

SADOWSKI, CL ^{[1
]}

KOBAYASHI, R ^{[1
]}

HERNANDEZ, N ^{[1
]}

机构：

[1] SUNY STONY BROOK, DEPT PHARMACOL, STONY BROOK, NY 11794 USA

来源：

NATURE | 1995年 / 374卷 / 6523期

关键词：

D O I：

10.1038/374653a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

THE TATA-box-binding protein TBP exists in the cell complexed with different sets of TBP-associated factors (TAFs)(1). In general, each of these TBP-TAP complexes is dedicated to transcription by a single RNA polymerase. Thus, SL1, TFIID and TFIIIB are required for transcription by polymerases I, II and III, respectively(2-10). Here we characterize a fourth TBP-TAF complex called SNAPc(11). Unlike the other TBP-TAF complexes, SNAPc is implicated in transcription by two types of polymerases; it is required for transcription of both the RNA polymerase II and III small-nuclear RNA genes and binds specifically to the proximal sequence element PSE, a non-TATA-box basal promoter element common to these two types of genes(11-13). In addition to TBP, SNAPc is composed of at least three TAFs, SNAP43, SNAP45 and SNAP50. The predicted amino-acid sequence of SNAP43 reveals that it corresponds to a new protein.

引用

页码：653 / 656

页数：4

共 16 条

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