ENHANCEMENT OF UROKINASE-INDUCED PLASMINOGEN ACTIVATION BY THE CATIONIC PROTEIN OF HUMAN EOSINOPHIL GRANULOCYTES

被引：36

作者：

DAHL, R

VENGE, P

机构：

[1] UNIV UPPSALA HOSP, DEPT CLIN CHEM, S-75014 UPPSALA, SWEDEN

[2] AARHUS KOMMUNE HOSP, DEPT INTERNAL MED, AARHUS, DENMARK

来源：

THROMBOSIS RESEARCH | 1979年 / 14卷 / 4-5期

关键词：

D O I：

10.1016/0049-3848(79)90115-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The highly cationic protein derived from the granules of human eosinophil granulocytes (ECP) enhanced the urokinase-induced plasminogen activation by a time- and dose-dependent mechanism but independent of temperature. The effect of ECP seemed directed towards the plasminogen molecule. The optimal reaction occurred at a mol:mol relationship between ECP and plasminogen of approximately 1:1 but no complex formation was demonatrated between the proteins. The eosinophil granulocyte may be a participant in fibrinolysis.

引用

页码：599 / 608

页数：10

共 24 条

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