AN ENANTIOSELECTIVE MICHAEL ADDITION OF SOFT NUCLEOPHILES TO PROCHIRAL ENONE CATALYZED BY (2-PYRROLIDYL)ALKYL AMMONIUM HYDROXIDE

被引：89

作者：

KAWARA, A

TAGUCHI, T

机构：

[1] TOKYO COLL PHARM,HACHIOJI,TOKYO 19203,JAPAN

[2] SANKYO CO LTD,PROC DEV LABS,SHINAGAWA KU,TOKYO 140,JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 47期

关键词：

D O I：

10.1016/S0040-4039(00)78503-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(S)-N-(2-Pyrrolidylmethyl)-N,N,N-trimethylammonium hydoxide catalyzes the asymmetric Michael addition of soft nucleophiles to enones with moderate to high enantiomeric excess through ion-pair rather than steric control.

引用

页码：8805 / 8808

页数：4

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