DIURNAL CHANGES IN PINEAL EXTRACELLULAR INDOLES OF FREELY MOVING RATS

被引：31

作者：

AZEKAWA, T ^{[1
]}

SANO, A ^{[1
]}

SEI, H ^{[1
]}

MORITA, Y ^{[1
]}

机构：

[1] UNIV TOKUSHIMA,SCH MED,DEPT PHYSIOL,3 KURAMOTO,TOKUSHIMA 770,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 132卷 / 01期

关键词：

DIURNAL RHYTHM; PINEAL GLAND; FREELY MOVING RAT; MICRODIALYSIS; SEROTONIN; N-ACETYLSEROTONIN;

D O I：

10.1016/0304-3940(91)90441-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We observed 24 h changes of 'extracellular' indoleamines in pineal microdialysates taken from freely moving rats under a 12 h light/12 h dark cycle. Pineal indoleamines in microdialysates were analyzed by high-performance liquid chromatography with electrochemical detection. Consequently, they exhibited marked diurnal variations, The diurnal level in the extracellular 5-HT, higher for the light and lower for the dark, was parallel to that in 5-hydroxyindoleacetic acid and diametrically opposite to that in N-acetylserotonin (NAS), The release of 5-HT into the extracellular space transiently increased for the first 2 h after the dark onset and then became lower during the dark.

引用

页码：93 / 96

页数：4

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