PHOSPHINIC ACID-BASED C-2-SYMMETRICAL INHIBITORS OF HIV-PROTEASE

被引：36

作者：

PEYMAN, A

BUDT, KH

SPANIG, J

RUPPERT, D

机构：

[1] Pharma Forschung Der Hoechst Ag, Frankfurt, D-65926

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1993年 / 32卷 / 12期

关键词：

D O I：

10.1002/anie.199317201

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As analogues of the transition state of peptide hydrolysis, phosphinic acid groups can be incorporated in a C2‐symmetrical peptide environment based on the geometry of the HIV‐protease. This leads to compounds such as 1, potent inhibitors of this key enzyme of the AIDS pathogens. R = 1‐naphthyl. (Figure Presented.) Copyright © 1993 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：1720 / 1722

页数：3

共 20 条

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