ANTAGONISM OF CLONIDINE ANTINOCICEPTION BY BUSPIRONE AND 1-(2-PYRIMIDINYL)-PIPERAZINE

被引：9

作者：

CAO, BJ

LI, WP

机构：

[1] Department of Pharmacology, Hunan Institute of Pharmaceutical Industry, Changsha

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 259卷 / 01期

关键词：

BUSPIRONE; 1-PP (1-(2-PYRIMIDINYL)-PIPERAZINE); CLONIDINE; ALPHA(2) ADRENOCEPTOR; ANTINOCICEPTION;

D O I：

10.1016/0014-2999(94)90160-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of pretreatment with buspirone and its major metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) on antinociception produced by clonidine were investigated in mice. Buspirone and 1-PP dose dependently attenuated the antinociceptive action of s.c. administered clonidine in the writhing and tail-flick assays. In both assays, 1-PP was more potent than buspirone in antagonizing clonidine-induced antinociception. After s.c. pretreatment with buspirone (8 mg/kg) and 1-PP (4 mg/kg), the antinociceptive ED(50) values of s.c. clonidine were significantly increased. The antagonistic effects of buspirone and 1-PP on clonidine-induced antinociception may be due to their alpha(2)-adrenoceptor antagonist activity.

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页码：75 / 78

页数：4

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