TRANSGENES AND GENE SUPPRESSION - TELLING US SOMETHING NEW

被引：179

作者：

DOUGHERTY, WG ^{[1
]}

PARKS, TD ^{[1
]}

机构：

[1] OREGON STATE UNIV,CTR GENE RES & BIOTECHNOL,CORVALLIS,OR 97331

来源：

CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 03期

关键词：

D O I：

10.1016/0955-0674(95)80096-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transgenes provide unique opportunities to assess the relationship between genotype and phenotype in an organism. In most cases, introduction and subsequent expression of a transgene will increase (with a sense RNA) or decrease (with an antisense RNA) the steady-state level of a specific gene product. However, a number of surprising observations have been made in the course of many transgenic studies. We develop a hypothesis that suggests that many examples of endogenous gene suppression by either antisense or sense transcripts are mediated by the same cellular mechanism.

引用

页码：399 / 405

页数：7

共 47 条

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