THE REGULATION AND EXPRESSION OF MHC CLASS-I GENES

被引：247

作者：

DAVID-WATINE, B

ISRAEL, A

KOURILSKY, P

机构：

[1] Unité de Biologie Moléculaire, Gene-U.277 INSERM UAC 115 CNRS Institut Pasteur, 75724 Paris Cédex 15

来源：

IMMUNOLOGY TODAY | 1990年 / 11卷 / 08期

关键词：

D O I：

10.1016/0167-5699(90)90114-O

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The expression of mouse MHC class I genes and their products in vivo reveals complex patterns of regulation. Different promoter elements, which are required for gene activation or modulation in response to various external stimuli, have now been characterized as well as the proteins that bind to them. As described here by Brigitte David-Watine and colleagues, the picture that has gradually emerged from these in vitro studies is of an intricate interplay of transacting factors that ultimately lead to the fine tuning of MHC class I expression in vivo. © 1990.

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页码：286 / 292

页数：7

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